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KMID : 0613820210310040425
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Journal of Life Science
2021 Volume.31 No. 4 p.425 ~ p.429
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Gene Expression of Early Growth Response Protein 1 in INS-1 Pancreatic β-cells Treated with Allomyrina dichotoma Hemolymph
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Kwon Ki-Sang
Lee Eun-Ryeong
Kwon O-Yu
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Abstract
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We have investigated the expression of early growth response protein 1 (EGR1) in INS-1 pancreatic β-cells treated with Allomyrina dichotoma hemolymph. The Korean rhinoceros beetle, A. dichotoma (Coleoptera: Scarabaeidae), is important in the insect industry for medical applications. We have already established a method for purification of A. dichotoma hemolymph that can be used in many experiments. EGR1 is reported as a multifunctional transcription factor that is implicated in virus infections. EGR1 has therefore been revealed as a major mediator and regulator in the physiological and pathological conditions of several cell and tissue types. New findings in this study are that A. dichotoma hemolymph, which promotes a dose- and time-dependent upregulation of EGR1 gene expression, shows an enhancement of this gene expression when combined with hypothermia or endoplasmic reticulum (ER) stress. These results suggest that A. dichotoma hemolymph may provide clues to EGR1-associated disease therapies involving gene regulation of EGR1.
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KEYWORD
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Allomyrina dichotoma early growth response protein 1 (EGR1), hemolymph, INS-1 pancreatic β-cells
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